HUNTINGTONS DISEASEHereditary that causes degeneration of
Cerebral cortex (mental deterioration
Basal ganglia (regulate voluntary movement)
PATHOPHYSIOLOGY
Involves a disturbance in neurotransmitter substance, primarily:
²áGamma amino butyric acid (GABA)
²âDopamine
â
GABA neurons in basal ganglia, frontal cortex and cerebellum are destroyed
GABA neurotransmitter production:
²an inhibitory neurotransmitter
â
excess of dopamine causes abnormal neurotransmitter along the affected pathway
chorea and mental deterioration
²enlargement of the ventricles in HD patient due to
atrophy of the head of the caudate from the neuronal loss
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