Amyotropic Lateral sclerosis
A progressive debilitating and fatal disease involving
degeneration of motor neurons
²loss of voluntary muscle control
²mental status is intact and not affected
ALS results from degeneration of:
²upper motor neurons in the medulla oblongata
²lower motor neurons in the spinal cord
PATHOPYSIOLOGY
Motor neurons in medulla oblongata and spinal cord die
â
Muscle they serves atrophy (loss of muscle tone
â
Weakness/paralysis of the muscle
â
Signs and symptoms vary according to what neuron is
affected and what muscle they serves
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